The drug lacks effects on the cyclooxygenase system, so does not cause injury to the esophagus, stomach, small intestine or large intestine, in contrast to NSAIDs. Comparison of an anti-inflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of taking acetaminophen and codeine doctor dose paracetamol patients with osteoarthritis of the knee. Paracetamol and NSAIDs have the benefit of bearing low risk of addiction, dependence, tolerance and withdrawal, but, unlike opioid medications, may damage the however, this is generally taken into account when compared to the danger of addiction. Pharmacokinetic comparison of acetaminophen products Tylenol Extended Relief vs regular Tylenol. The active treatments were more effective than placebo, and neither strength of ibuprofen was different from however, ibuprofen 400 mg was significantly more effective than ibuprofen 200 mg in patients overall evaluation. However, the study, which originally was planned to enroll 2500 patients, was stopped at 1400 patients for insufficient financial resources, he points out.