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And when Arkansas opened its first methadone maintenance clinic in December 1993, the vast majority of its clients were not admitted for heroin addiction, but for semisynthetic opioid abuse. Properly managed medical use of pain relievers is safe and rarely causes clinical addiction, defined as compulsive, often uncontrollable use of drugs. Experience indicates reasonable starting dose of OxyContin for patients who are taking non-opioid analgesics and oxycontin lawyer columbus require continuous around-the-clock therapy for an extended period of time is 10 mg q12h. There is no clinical information on dosing intervals shorter than q12h.